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ISTO Technologies, Inc. Appoints Blake Miles as Vice President of Sales

Nov 1, 2007

St. Louis, Missouri, November, 2007 – ISTO Technologies, Inc. a privately held orthobiologics company, today announced the appointment of Blake Miles as Vice President of Sales.

ISTO President and CEO Mitchell Seyedin said, “We are pleased to attract a proven talent from the medical device industry, with an impressive knowledge of orthobiologic products.” Prior to joining ISTO, Blake was a Regional Sales Manager with a distributorship for Depuy Spine, Inc. a global designer, manufacturer, and supplier of spinal devices and a subsidiary of Johnson & Johnson. Mr. Miles has 14 years of sales and marketing experience. His tenure in medical sales included successful senior level sales positions with Medtronic Sofamor Danek, Ansell Healthcare, Kos Pharmaceutical, and Physican Sales & Service. “Throughout his career, Blake has shown leadership and an entrepreneurial spirit in managing successful sales teams in the orthopedic field,” said Seyedin. Mr. Miles will organize and drive a sales distributor network to launch ISTO’s first commercial product, InQu, a bone graft extender and substitute.

InQu represents a new class of synthetic biomaterial scaffold designed to optimize structural and biological properties to support bone cell growth. InQu is a biopolymer composite of hyaluronic acid which is entangled within the three-dimensional backbone created by synthetic polyester. Hyaluronic acid, a ubiquitous component of natural tissue, is known to play a predominant role in tissue morphogenesis, cell migration, adhesion, and cell differentiation.

In addition to its biomaterial platform technology, ISTO is also developing cartilage regeneration products centered on its patented cell-based technology. Cartilage regeneration is often called the “holy grail” of the orthopedic industry because of its potential to restore function to damaged joints that otherwise have limited healing potential. Cartilage serves as a “shock absorber” protecting all joints, including spinal discs, from the wear and tear experienced during motion. ISTO’s first cartilage product is currently in clinical trials.

About ISTO Technologies, Inc.
ISTO Technologies, Inc. is an orthobiologics company focused on developing differentiated products for sports medicine, spinal therapy, and trauma. ISTO’s products are intended for the repair and regeneration of damaged or injured cartilage and bone. For additional information on ISTO, please visit our website at www.istobiologics.com or contact the company at 314-995-6049.

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