The Power of Biosynthetics
A Winning Composition
For decades, biomaterials have been the building blocks of countless medical procedures. As our understanding of biological structures and compositions advances, these tools are becoming increasingly sophisticated and effective. On the cutting edge of innovation, ISTO’s patented biosynthetic platform, currently applied in the InQu® bone graft, is composed of synthetic poly(lactide-co-glycolide) (PLGA) entangled with hyaluronic acid (HyA), two components with a long history of safe and effective clinical use.
The structural characteristics of PLGA make it an ideal building material for the construction of three-dimensional tissue scaffolds. HyA is entangled within this structure, creating a microenvironment that mimics what is naturally found in bone marrow and other connective tissues. In comparison to traditional ceramic bone grafts, this composition supports rapid integration into surrounding tissue when introduced into the body1.
Our unique PLGA/HyA combination scaffold supports bone formation. HyA is a natural component of human tissue and has been shown to be safe when used in similar applications2,3. PLGA creates an osteoconductive surface well recognized to support the body’s natural bone growth as it undergoes resorption at the implantation site4,5.
The HyA/PLGA composition is central to ISTO’s bone graft and extender InQu®, a best-in-class biosynthetic that is available in three distinct, sterile configurations: Paste Mix Plus, Matrix, and Granules. Its versatility, ease of use, and scientifically proven effectiveness make it a viable choice for a variety of spinal and orthopedic procedures6.
Additionally, ISTO’s unique biosynthetic platform has the potential to impact an array of clinical applications, and could redefine the field of tissue regeneration. Because of this, ISTO is continuously exploring new directions to focus its research.