Arteriocyte is now a part of Isto Biologics.

Science

Biomaterial

The Power of Biosynthetics

A Winning Composition

For decades, biomaterials have been the building blocks of countless medical procedures. As our understanding of biological structures and compositions advances, these tools are becoming increasingly sophisticated and effective. On the cutting edge of innovation, ISTO’s patented biosynthetic platform, currently applied in the InQu® bone graft, is composed of synthetic poly(lactide-co-glycolide) (PLGA) entangled with hyaluronic acid (HyA), two components with a long history of safe and effective clinical use.

The structural characteristics of PLGA make it an ideal building material for the construction of three-dimensional tissue scaffolds. HyA is entangled within this structure, creating a microenvironment that mimics what is naturally found in bone marrow and other connective tissues. In comparison to traditional ceramic bone grafts, this composition supports rapid integration into surrounding tissue when introduced into the body1.

science_biomaterialOur unique PLGA/HyA combination scaffold supports bone formation. HyA is a natural component of human tissue and has been shown to be safe when used in similar applications2,3. PLGA creates an osteoconductive surface well recognized to support the body’s natural bone growth as it undergoes resorption at the implantation site4,5.

The HyA/PLGA composition is central to ISTO’s bone graft and extender InQu®, a best-in-class biosynthetic that is available in three distinct, sterile configurations: Paste Mix Plus, Matrix, and Granules. Its versatility, ease of use, and scientifically proven effectiveness make it a viable choice for a variety of spinal and orthopedic procedures6.

Additionally, ISTO’s unique biosynthetic platform has the potential to impact an array of clinical applications, and could redefine the field of tissue regeneration. Because of this, ISTO is continuously exploring new directions to focus its research.

“ISTO’s biomaterial technology incorporates biologic and synthetic materials to promote tissue healing by uniquely combining a bio-resorbable polymer that provides structural support with a biomaterial that is friendly to bone growth during healing.”

—Mary Vonesh, Chief Financial Officer

  1. Ogston AG, Sherman TF. Effects of hyaluronic acid upon diffusión of solutes and flow of solvent. J Physiol 1961; 17:1–8.
  2. Hall CL, Wang C, Lange LA, Turley EA. Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity. J Cell Biol 1994; 126:575–588.
  3. Tool, BP. Hyaluronan in Morphogenesis. Journal of Internal Medicine 1997; 242:35-40.
  4. Hollinger, JO. Preliminary report on the osteogenic potential of a biodegradable copolymer of polylactic acid (PLA) and polyglycolide (PGA). J Biomed Mater Res 1983; 17:71–82.
  5. Athanasiou KA, Neiderauer G, Agrawal CM. Sterilization, toxicity, biocompatibility and clinical applications of polylactic acid/polyglycolic acid copolymers. Biomaterials 1996; 17:93–102.
  6. Walsh WR, Oliver RA, Gage G, et al. Application of resorbable poly(lactide-co-glycolide) with entangled hyaluronic acid as an autograft extender for posterolateral intertransverse lumbar fusions in rabbits. Tissue Eng Part A. 2011;17:213–220. [Epub 2010 Oct 8.]

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