bone-marrow derived cells
Ambikaipalan A, Wong JM, and Khan WS. Preclinical and clinical studies on the use of stem cells for bone repair: a systematic review. Current Stem Cell Research & Therapy. 8: 210-2016. 2013.
Harrell DB, et al. Non-hematopoietic essential functions of bone marrow: a review of scientific and clinical literature and rationale for treating bone defects. Orthop Rev. 7:5691. 2015. doi: 10.40181/or2015.5691.
cardiovascular & infection control
Jeevananthan V, et al. Adult bone marrow cell therapy improves survival and induces long-term improvement in cardiac parameters: a systematic review and meta-analysis. Circulation. 2012; doi: 10.1161/circulationaha.111.086074.
Hernigou P, et al.  Local transplantation of bone marrow concentrated granulocytes precursors can cure without antibiotics infected non-union of polytraumatic patients in absence of bone defectInt Orthop.  40:2331-2338, 2016.
Patel AN, et al. Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients. J Cardiothorac Surg. 2016. 11(1):62. doi: 10.1186/s13019-016-0452-9
Cell-Separation technology
Aronowitz JA, et al. Mechanical versus enzymatic isolation of stromal vascular fraction cells from adipose tissue. Springerplus. 4:713. 2015. doi: 10.11861540064-015-1509-2.
Guven S, et al. Validation of an automated procedure to isolate human adipose tissue–derived cells by using the Sepax® technology. TISSUE ENGINEERING: Part C. 18(8). 2012.
Zinno F, et al. Processing of hematopoietic stem cells from peripheral blood before cryopreservation: use of a closed automated system. Transfusion. 51(12): 2656-2663. 2011.
critical limb ischemia
Iafrati, M.D., et al. Early results and lessons learned from a multicenter, randomized, double-blind trial of bone marrow aspirate concentrate in critical limb ischemia.  Journal of Vascular Surgery. 54(6): 1650-1658. 2011.
Liang TW, et al. Autologous bone marrow mononuclear cell therapy for critical limb ischemia is effective and durable. J Vasc Surg. 63(6): 1541-1546. 2016.
Ponemone V, et al.  Safety and effectiveness of bone marrow cell concentrate in the treatment of chronic critical limb ischemia utilizing a rapid point-of-care system. Stem Cells Int. 2017 doi: 10.1155/2017/413762
general orthopedics
Connolly J, et al. Autologous marrow injection as a substitute for operative grafting of tibial nonunions. Clinical Orthopaedics and Related Research. 263: 259-270. 1991.
Ganji V, et al. Treatment of osteonecrosis of the femoral head with implantation of autologous bone-marrow cells: a pilot study. Journal of Bone and Joint Surgery. 1153-1160. 2004.
Hendrich C, et al. Safety of autologous bone marrow concentrate transplantation: initial experiences in 101 patients. Orthop Rev. 1:e32. 2009.
Hernigou P, et al. Cancer risk is not increased in patients treated for orthopaedic diseases with autologous bone marrow cell concentrate. J Bone Joint Surg Am. 95 (24): 2215-2221. 2013.
Hernigou P, Poignard A, Beaujean F, and Rouard H. Percutaneous autologous bone marrow grafting for nonunions. Influence of the number and concentration of progenitor cells. J Bone Joint Surg Am. 87:1430-1437. 2005.
spinal disc injection
Haufe SMW and Mork AR. Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral disc. Stem Cells Dev. 15:136-137. 2006.
Pettine KA, et al.  Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months. Stem Cells. 33:146-156. 2015.
Tuakli-Worsonu YA, et al. Lumbar intradiskal platelet-rich plasma (PRP) injections: A prospective, double blind, randomized controlled study. PMR doi: 10.1016/j.pmrj. 2015.08.010, 2016.
Spinal fusion
Ajiboye, R.M., et al. Clinical and radiographic outcomes of concentrated bone marrow aspirate with allograft and demineralized bone matrix for posterolateral and interbody lumbar fusion in elderly patients. Eur Spine J. 24: 2567. 2015. doi:10.1007/s00586-015-4117-5.
Gan Y, et al. The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion. Biomaterials. (29): 3973-3982. 2008.
Hart R, et al. Allograft alone versus allograft with bone marrow concentrate for the healing of the instrumented posterolateral lumbar fusion. Spine J. 14(7): 1318-1324. 2014.
Johnson, RG.  Bone marrow concentrate with allograft equivalent to autograft in lumbar fusions. Spine. 39(9): 695-700. 2014.
Vadala G, et al. Use of autologous bone cells concentrate enriched with platelet-rich fibrin on corticocancellous bone allograft for posterolateral multilevel cervical fusion.  J Tiss Eng Regen Med. 2: 515-520. 2008
Sports Medicine & Pain Management
Jang SJ, et al. Platelet-rich plasma (PRP) injections as an effective treatment for early osteoarthritis. Eur J Orthop Surg Traumatol. 2013;23: 573-580. doi: 10.1007/s00590-012-1037-5
Franklin, S. et al. The use of platelet-rich plasma for percutaneous treatment of tendinopathies. Operative Techniques in Orthopaedics. 2013;23(2):63-68.
Finnoff JT, et al. Treatment of chronic tendinopathy with ultrasound-guided needle tenotomy and platelet-rich plasma injection. American Academy of Physical Medicine and Rehabilitation. 2011;3(10):900-11. doi: 10.1016/j.pmrj.2011.05.015
Lee J, et al. Platelet-rich plasma injections with needle tenotomy for gluteus medius tendinopathy. The Orthopaedic Journal of Sports Medicine. 2016;4(11). DOI: 10.1177/2325967116671692
Podesta L, et al. Treatment of partial ulnar collateral ligament tears in the elbow with platelet-rich plasma. The American Journal of Sports Medicine. 2013;41(7):1689-94. doi: 10.1177/0363546513487979
Scollon-Grieve KL, et al. Platelet-rich plasma injection for partial tendon tear in a high school athlete: a case presentation. American Academy of Physical Medicine and Rehabilitation. 2011;3(4):391-5. doi: 10.1016/j.pmrj.2010.11.008
Sampson S, et al. Platelet-rich plasma therapy as a first line treatment for severe Achilles tendon tear: a case report. International Journal of Therapy and Rehabilitation. 2011;18(2):101-106.
Wilson JJ, et al. Platelet-rich plasma for the treatment of chronic plantar fasciopathy in adults: a case seriesFoot & Ankle Specialist. 2014;7:61-7. doi: 10.1177/1938640013509671 
Surgical Orthopedics
Everts PA, et al. Exogenous application of platelet-leukocyte gel during open subacromial decompression contributes to improved patient outcome. Eur Surg Res. 2004;40:203–210. DOI: 10.1159/000110862
Hannon CP, et al. Arthroscopic bone marrow stimulation and concentrated bone marrow aspirate for osteochondral lesions of the talus: a case-control study of functional and magnetic resonance observation of cartilage repair tissue outcomes. Arthroscopy. 2016;32(2): 339-347.
Krych A, et al. Bone marrow concentrate improves early cartilage phase maturation of a scaffold plug in the knee: a comparative magnetic resonance imaging analysis to platelet-rich plasma and control. Am J Sports Med. 2016;44: 91. DOI: 10.1177/0363546515609597
Lee GW, et al. Is platelet-rich plasma able to enhance the results of arthroscopic microfracture in early osteoarthritis and cartilage lesion over 40 years of age? Eur J Orthop Surg Traumatol. 2013;23(5):581-7. doi:10.1007/s00590-012-1038-4
Rodriguez-Collazo ER, et. al. Combined use of the Ilizarov method, concentrated bone marrow aspirate (cBMA), and platelet-rich plasma (PRP) to expedite healing of bimalleolar fracturesStrategies in Trauma and Limb Reconstruction. 2015;10(3):161-166. doi: 10.1007/s11751-015-0239-x
Rodriguez-Collazo ER, et al. A retrospective look at integrating a novel regenerative medicine approach in plastic limb reconstruction. Plast Reconstr Surg Glob Open. 2017;5(1):e1214. doi: 10.1097/GOX.0000000000001214
Rodriguez-Collazo ER.  Combined use of the illizarov method, concentrated bone marrow aspirate. Orthopedics & Rheumatology. 2015;1(3): 555561.
Rodriguez-Collazo ER, et al. Bone marrow concentrate enriched in platelet growth factors combined with de-mineralized bone matrix for complex revision and complex lower limb arthrodesis. Orthop Rheumatol Open Access J. 2015;1(2): 555558.
Rodriguez-Collazo ER, et al. Combined use of the Ilizarov method, concentrated bone marrow aspirate (cBMA), and platelet-rich plasma (PRP) to expedite healing of bimalleolar fractures. Strat Traum Limb Recon. 2015;10:161-166. DOI 10.1007/s11751-015-0239-x
Skoff HD. Revision rotator cuff reconstruction for large tears with retraction: a novel technique using autogenous tendon and autologous marrow. Am J Orthop. 2015;44(7):326-331.
Smyth N, et al. The effect of platelet-rich plasma on autologous osteochondral transplantation: an in vivo rabbit model. J Bone Joint Surg Am. 2013 Dec 18;95(24):2185-93. doi: 10.2106/JBJS.L.01497
Vavken P, et al. The effect of platelet concentrates on graft maturation and graft-bone interface healing in ACL reconstruction in human patients: A systematic review of controlled trials. Arthroscopy. 2011;27(11):1573-83. doi: 10.1016/j.arthro.2011.06.003
Vogrin M, et al. The effect of platelet-derived growth factors on knee stability after anterior cruciate ligament reconstruction: a prospective randomized clinical study. Wien Klin Wochenschr. 2010;122 (2): 91–95. doi: 10.1007/s00508-010-1340-2
Zavadil D, et al. Autologous platelet gel and platelet poor plasma reduce pain with total shoulder arthroplasty. JECT. 2007;39:177–182.
Zhong W, et al. In vivo comparison of the bone regeneration capability of human bone marrow concentrates vs. Platelet-rich plasma. PLoS ONE. 2012;7(7): e40833. doi:10.1371/journal.pone.0040833
System Performance & Basic Science
Boakye L, et al. Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model. World J Orthop. 2015; 6(11): 961-969. DOI: 10.5312/wjo.v6.i11.961
Cassano JM, et al. Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration. Knee Surg Sports Traumatol Arthrosc. 2016. doi: 10.1007/s00167-016-3981-9
Castillo TN, et al. Comparison of growth factor and platelet concentration from commercial platelet-rich plasma separation systems. Am J Sports Med. 2011;39(2):266-71. doi: 10.1177/036354651038751
Christensen K, et al. Autologous platelet gel: an in vitro analysis of platelet-rich plasma using multiple cycles. JECT. 2006;38:249–253.
Degen RM, et al. Commercial separation systems designed for preparation of platelet-rich plasma yield differences in cellular composition. HSS J. 2017;13(1):75-80. doi: 10.1007/s11420-016-9519-3
Dhurat R, et al. Principles and methods of preparation of platelet-rich plasma: a review and author's perspective. J Cutan Aesthet Surg. 2014;7(4):189-97. doi: 10.4103/0974-2077.150734
Dohan E, et al. Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). Trends Biotechnol. 2009;27(3):158-67. doi: 10.1016/j.tibtech.2008.11.009
Fitzpatrick J, et al. Analysis of platelet-rich plasma extraction variations in platelet and blood components between 4 common commercial kits. Orthop J Sports Med. 2017;5(1):2325967116675272. doi: 10.1177/2325967116675272
Gersch RP. Platelet rich plasma augments adipose-derived stem cell growth and differentiation. Aesthet Surg J. 2017;1;37(6):723-729. doi: 10.1093/asj/sjw235
Joshi SU, et al. Patient-derived and intraoperatively formed biomaterial for tissue engineering. Methods Mol Biol. 2017;1553:265-272. doi: 10.1007/978-1-4939-6756-8_21
Kelc R, et al. Platelet-rich plasma, especially when combined with a TGF-β inhibitor promotes proliferation, viability and myogenic differentiation of myoblasts in vitro. PLoS ONE. 10(2):e0117302. doi:10.1371/journal.pone.0117302
McDaniel JS, et al. Alternatives to autograft evaluated in a rabbit segmental bone defect. Int Orthop. 2016;40(1):197-203. doi: 10.1007/s00264-015-2824-5
Mishra A, et al. Buffered platelet-rich plasma enhances mesenchymal stem cell proliferation and chondrogenic differentiation. Tissue Engineering. 2009;15(3):431-5. doi: 10.1089/ten.tec.2008.0534
Ogura T, et al. A novel method of preparing platelet-rich plasma (PRP): an automatic blood separation device “Magellan.” Wound Repair and Regeneration. 2013. 21(1):A2.
O’Shea CM, et al. Comparison of platelet counting technologies in equine platelet concentrates. Vet Surg. 2015;44(3):304-13. doi: 10.1111/j.1532-950X.2014.12290.x
Pochini A de C, et al. Analysis of cytokine profile and growth factors in platelet-rich plasma obtained by open systems and commercial columnsEinstein. 2016;14(3):391-397. doi:10.1590/S1679-45082016AO3548
Whole Blood vs. bone marrow
Betsch M, et al. Bone marrow aspiration concentrate and platelet rich plasma for osteochondral repair in a porcine osteochondral defect model. PLOS One.  8(8): e71602. 2013.
Cassano, J.M., Kennedy, J.G., Ross, K.A. et al. Bone marrow concentrate and platelet-rich plasma differ in cell distribution and interleukin 1 receptor antagonist protein concentration. Knee Surg Sports Traumatol Arthrosc. 2016. doi:10.1007/s00167-016-3981-9
Wound Healing
Englert S, et al. Autologous platelet gel applications during cardiovascular surgery: effect on wound healing. JECT. 2005;37:148–152.
Hom D, et al. The healing effects of autologous platelet gel on acute human skin wounds. Arch Facial Plast Surg. 2007; 9(3):174-83. doi: 10.1001/archfaci.9.3.174
Kakudo N, et al. The use of autologous platelet-rich plasma in the treatment of intractable skin ulcer: A case series. Open Journal of Regenerative Medicine. 2012; 01(03):29-32. doi: 10.4236/ojrm.2012.13005
Litmathe J, et al. The use of autologous platelet gel (APG) for high-risk patients in cardiac surgery – is it beneficial? Perfusion. 2009. 24(6):381-7. doi: 10.1177/0267659109358283
Patel AN, et al. Evaluation of autologous platelet rich plasma for cardiac surgery: outcome analysis of 2000 patients. J Cardiothorac Surg. 2016. 11(1):62. doi: 10.1186/s13019-016-0452-9
Saratzis N, et al. Non-activated autologous platelet-rich plasma for the prevention of inguinal wound-related complications after endovascular repair of abdominal aortic aneurysms. J Extra Corpor Technol. 2008; 40(1):52-6.
Vang S, et al. Autologous platelet gel in coronary artery bypass grafting: effects on surgical wound healing. JECT. 2007;39:31–38.
other applications
Brady C, et aI. Use of autologous platelet gel in bariatric surgery. J Extra Corpor Technol. 2006; 38:161-164.
Cervelli V, et al. P.R.L. Platelet rich lipotransfert: our experience and current state of art in the combined use of fat and PRP. Biomed Res Int. 2013. doi: 10.1155/2013/434191
Gentile P, et al. A comparative translational study: the combined use of enhanced stromal vascular fraction and platelet-rich plasma improves fat grafting maintenance in breast reconstruction. Stem Cells Transl Med. 2012;1(4):341-51. doi: 10.5966/sctm.2011-0065
Rademakers LM, et al. Stability of an autologous platelet clot in the pericardial sac: An experimental and clinical study. J Thorac Cardiovasc Surg. 2009;137(5):1190-4. doi: 10.1016/j.jtcvs.2008.10.012
Wehberg KE, et al. Intramyocardial injection of autologous platelet-rich plasma combined with transmyocardial revascularization. Cell Transplant. 2009;18(3):353-9. doi: 10.3727/096368909788534988
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